Prothrombin gene variants in non-Caucasians with fetal loss and intrauterine growth retardation.
J Mol Diagn
; 5(4): 250-3, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14573785
ABSTRACT
Thrombotic predisposition may affect pregnancy outcome, but in non-Caucasians the contributing genetic factors are poorly characterized. Two recently identified prothrombin gene mutations (20209C>T and 20221C>T) have been observed in non-Caucasian patients with thrombosis. The mutations are located near the commonly identified variant 20210G>A and have not been reported in Caucasian patients. The authors report a novel connection with pregnancy complications. The identification of sequence variants other than 20210G>A in the 3'-untranslated region of the prothrombin gene suggests that additional nucleotide substitutions may contribute to the development of thrombotic events and adverse pregnancy outcomes, especially in less well-characterized populations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Negro ou Afro-Americano
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Protrombina
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Aborto Espontâneo
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Povo Asiático
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Retardo do Crescimento Fetal
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Female
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Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article