Heterocyclic ketones as inhibitors of histone deacetylase.

Vasudevan, Anil; Ji, Zhiqin; Frey, Robin R; Wada, Carol K; Steinman, Douglas; Heyman, H Robin; Guo, Yan; Curtin, Michael L; Guo, Jun; Li, Junling; Pease, Lori; Glaser, Keith B; Marcotte, Patrick A; Bouska, Jennifer J; Davidsen, Steven K; Michaelides, Michael R

Vasudevan, Anil; Ji, Zhiqin; Frey, Robin R; Wada, Carol K; Steinman, Douglas; Heyman, H Robin; Guo, Yan; Curtin, Michael L; Guo, Jun; Li, Junling; Pease, Lori; Glaser, Keith B; Marcotte, Patrick A; Bouska, Jennifer J; Davidsen, Steven K; Michaelides, Michael R.

Afiliação

Vasudevan A; Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. anil.vasudevan@abbott.com

Bioorg Med Chem Lett ; 13(22): 3909-13, 2003 Nov 17.

Article em En | MEDLINE | ID: mdl-14592473

ABSTRACT

ABSTRACT

Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition.

Assuntos

Inibidores Enzimáticos/farmacologia; Compostos Heterocíclicos/farmacologia; Inibidores de Histona Desacetilases; Cetonas/farmacologia; Inibidores Enzimáticos/química; Cetonas/química; Cinética; Relação Estrutura-Atividade

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Inibidores de Histona Desacetilases / Compostos Heterocíclicos / Cetonas Idioma: En Ano de publicação: 2003 Tipo de documento: Article

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