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Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3.
Takeuchi, Kumiko; Kohn, Todd J; Honigschmidt, Nicholas A; Rocco, Vincent P; Spinazze, Patrick G; Atkinson, Steven T; Hertel, Larry W; Nelson, David L; Wainscott, D Bradley; Ahmad, Laura J; Shaw, Janice; Threlkeld, Penny G; Wong, David T.
Afiliação
  • Takeuchi K; Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA. ktak@lilly.com
Bioorg Med Chem Lett ; 13(22): 3939-42, 2003 Nov 17.
Article em En | MEDLINE | ID: mdl-14592479
ABSTRACT
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols further improved the in vitro binding affinities and functional antagonism.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Inibidores Seletivos de Recaptação de Serotonina / Propanóis / Antagonistas do Receptor 5-HT1 de Serotonina / Antidepressivos Idioma: En Ano de publicação: 2003 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Inibidores Seletivos de Recaptação de Serotonina / Propanóis / Antagonistas do Receptor 5-HT1 de Serotonina / Antidepressivos Idioma: En Ano de publicação: 2003 Tipo de documento: Article