Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 3.
Bioorg Med Chem Lett
; 13(22): 3939-42, 2003 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-14592479
ABSTRACT
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols further improved the in vitro binding affinities and functional antagonism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Inibidores Seletivos de Recaptação de Serotonina
/
Propanóis
/
Antagonistas do Receptor 5-HT1 de Serotonina
/
Antidepressivos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article