Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.
Bioorg Med Chem Lett
; 13(22): 3947-50, 2003 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-14592481
ABSTRACT
Monoacid-based PTP1B inhibitors with improved physiochemical properties have been investigated. A (2-hydroxy-phenoxy) acetic acid-based phosphotyrosyl mimetic has been linked with an optimized second arylphosphate binding site ligand to produce compound 20 with low micromolar potency against PTP1B, good selectivity over TCPTP (20-fold) and high cell permeability in the Caco-2 system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Fosfatases
/
Inibidores Enzimáticos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article