Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.
Bioorg Med Chem Lett
; 13(22): 4001-5, 2003 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-14592494
ABSTRACT
Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Alquil e Aril Transferases
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article