The role of the matrix metalloproteinases in human endometrial and ovarian cycles.
Eur J Obstet Gynecol Reprod Biol
; 111(2): 109-21, 2003 Dec 10.
Article
em En
| MEDLINE
| ID: mdl-14597237
ABSTRACT
The matrix metalloproteinases (MMPs) are part of an expanded family of proteins called the astacin family of zinc metalloproteinases. The MMPs, probably balanced by their tissue inhibitors of metalloproteinases (TIMPs), are essential effectors of developmental processes participating in cell migration, cell proliferation, apoptosis and tissue morphogenesis. The MMPs regulate the function of biologically active molecules as well as fulfilling an important role in endothelial cell invasion, angiogenesis and in tumor progression. The dynamic normal physiology of the human reproductive system involves almost all of the above-mentioned aspects of MMPs activity. This review presents and discusses new insights into the role of MMPs, and their TIMPs, in human endometrial cycle and ovarian function.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Metaloproteinases da Matriz
/
Endométrio
/
Ciclo Menstrual
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article