Update on gene therapy for cystic fibrosis.
Curr Opin Mol Ther
; 5(5): 489-94, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-14601517
ABSTRACT
Cystic fibrosis (CF) is a monogenic autosomal recessive disease. Although several organs are affected, severe lung disease is the cause of most morbidity and mortality in CF individuals. The first clinical trials in CF patients were carried out in 1993, and to date, 29 trial protocols have been published. Although proof-of-principle for gene transfer to the lung has been established, efficiency is generally low. Steady progress has been made over the last two years and key papers, including recent advances in viral and nonviral gene transfer agents, will be reviewed here.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Genética
/
Técnicas de Transferência de Genes
/
Regulador de Condutância Transmembrana em Fibrose Cística
/
Fibrose Cística
Tipo de estudo:
Guideline
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article