Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.
Arch Pharm Res
; 26(10): 785-95, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-14609124
ABSTRACT
For the development of new anticonvulsive agents, GABAmimetics such as nipecotic acid, isonipecotic acid, gamma-aminobutyric acid (GABA), gamma-vinyl GABA (vigabatrin) and valproic acid were covalently coupled through an ester bond by a two-carbon linker chain as potential pro-drugs and evaluated for their anticonvulsive activities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbono
/
Pró-Fármacos
/
Desenho de Fármacos
/
Dimerização
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article