[Antineutrophil cytoplasmic antibodies--ANCA]. / Protilátky proti cytoplazme neutrofilních leukocytu--ANCA.
Cas Lek Cesk
; 131(19): 577-81, 1992 Oct 09.
Article
em Cs
| MEDLINE
| ID: mdl-1464072
ABSTRACT
Antibodies against cytoplasm of neutrophil leucocytes (ANCA) with a high sensitivity are found in idiopathic necrotizing vasculitis and idiopathic glomerulonephritis with formation of sickles (IGS). C-ANCA are directed against the myeloid lysosomal enzyme--proteinase 3 and are found above all in Wegener's granulomatosis and microscopic polyarteritis. P-ANCA are directed mainly against myeloperoxidase, less against leucocytic elastase or lactoferrin and are found above all in microscopic polyarteritis, IGS, polyarteritis nodosa or Churg-Strauss syndrome. The elevated ANCA level correlates with the activity of the disease or precedes a relapse. These autoantibodies activate probably neutrophil leucocytes for respiratory exacerbation and degranulation which may lead to extensive tissue damage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Citoplasma
/
Neutrófilos
Limite:
Humans
Idioma:
Cs
Ano de publicação:
1992
Tipo de documento:
Article