Synthesis of novel 4'-substituted 16-membered ring macrolide antibiotics derived from leucomycins.
Bioorg Med Chem Lett
; 14(2): 519-21, 2004 Jan 19.
Article
em En
| MEDLINE
| ID: mdl-14698194
ABSTRACT
A series of novel 4'-substituted 16-membered ring macrolides was synthesized by the cleavage of the mycarose sugar and subsequent modification of 4'-hydroxyl group. This new class of macrolides antibiotics is acid stable. The synthetic methodology described here is expected to find application in the synthesis of new generation of macrolides that target the emerging bacterial resistance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucomicinas
/
Macrolídeos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article