Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism.
Biol Psychiatry
; 55(3): 317-9, 2004 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-14744475
ABSTRACT
BACKGROUND:
Guanine nucleotide-binding proteins (G-proteins) have been implicated in affective disorders, with reports of altered signal transduction and G-protein levels. Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism.METHODS:
European SAD patients (n = 159) and matched controls (n = 159) were genotyped for the C825T. Seasonality and diurnal preference were investigated in subsets of the material (n = 177 and 92, respectively).RESULTS:
We found no association between C825T and SAD (chi(2) =.09, p =.96) or seasonality (F = 1.76, p =.18). There was some evidence for an effect on diurnal preference but only in the control group (n = 46, t = -2.8, Bonferroni corrected p =.045).CONCLUSIONS:
These results suggest that the G-protein beta-3-subunit 825 T-allele does not play a major role in susceptibility to seasonal affective disorder in the population studied.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Afetivo Sazonal
/
Proteínas Heterotriméricas de Ligação ao GTP
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article