Neurogenesis in the subependymal layer of the adult rat: a role for neuroactive derivatives of progesterone.
Ann N Y Acad Sci
; 1007: 335-9, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14993066
ABSTRACT
The subependymal layer (SEL) of the adult mammalian brain provides a continuous supply of newborn cells that migrate to the olfactory bulb (OB) where they differentiate into interneurons. These newly generated cells migrate tangentially to the OB within a dense meshwork of astrocytic cells, organized to form tangentially oriented channels (glial tubes). The central nervous system is able to synthesize a variety of steroids. Among these, we analyzed the effects of progesterone (P) and its neuroactive metabolites dihydroprogesterone (DHP) and tetrahydroprogesterone (THP), administered by intraventricular injection, on the SEL of the adult rat. We found that THP and DHP, but not their precursor P, modify glial tubes organization and decrease immunoreactivity for glial associated proteins in SEL astrocytes. Moreover P metabolites reduce the proliferative activity within the SEL.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progesterona
/
Epêndima
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article