Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor.
J Med Chem
; 47(6): 1319-21, 2004 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-14998320
ABSTRACT
N,N'-Diarylureas were prepared, and the structure-activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, which in addition was shown to be functionally active both in vitro against human neutrophils and in vivo in rabbit models of ear edema and neutropenia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Fenilureia
/
Receptores de Interleucina-8B
/
Anti-Inflamatórios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article