The influence of dietary essential fatty acids on uterine C20 and C22 fatty acid composition.
Prostaglandins Leukot Essent Fatty Acids
; 46(2): 111-21, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1502249
ABSTRACT
The effect of dietary fatty acids on uterine fatty acid composition was studied in rats fed control diet or semi-synthetic diet supplemented with 1.5 microliter/g/day evening primrose oil (EPO) or fish oil (FO). Diet-related changes in uterine lipid were detected within 21 days. Changes of 2- to 20-fold were detected in the uterine n-6 and n-3 essential fatty acids (EFA) and in certain saturated and monounsaturated fatty acids. The FO diet was associated with higher uterine C20 and C22 n-3, and the EPO diet, with higher uterine n-6 fatty acid. High uterine C182 n-6 was detected in neutral lipid (NL) of rats fed high concentrations of this fatty acid, but there was little evidence of selective incorporation or retention of C182 n-6 by uterine NL. The incorporation of EFA into uterine phospholipids (PL) was greater than NL EFA incorporation, and uterine PL n-3/n-6 ratios showed greater diet dependence. Tissue/diet fatty acid ratios in NL and PL also indicated preferential incorporation/synthesis of C161 n-9, and C160, and there was greater incorporation of C120 and C140 into uteri of rats fed EPO and FO. Replacement of 50-60% of arachidonate with n-3 EFA in uterine PL may inhibit n-6 EFA metabolism necessary for uterine function at parturition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Útero
/
Gorduras Insaturadas na Dieta
/
Ácidos Graxos Essenciais
/
Ácidos Graxos
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article