Synthesis of 2'-azidoethyl trisaccharide, alpha-D-Gal-(1-->2)-6d-alpha-D-altro-Hepp-(1-->3)-beta-D-GlcNAc, an O-antigenic repeating unit of C. jejuni O:23 and O:36.
Arch Pharm Res
; 27(2): 143-50, 2004 Feb.
Article
em En
| MEDLINE
| ID: mdl-15022713
ABSTRACT
A trisaccharide, the O-antigenic repeating unit of C. jejuni serotype O23 and O36, was synthesized as a 2'-azidoethyl glycoside by block addition of perbenzylated thiogalactoside donors to alpha-altroHepp-(1-->3)-GlcNPhth disaccharide acceptor in presence of IDCP promoter. The alpha-linked altroheptopyranoside moiety in the glycosyl acceptor was effectively prepared by Swern oxidation of alpha-mannohepp-(1-->3)-GlcNPhth disaccharide followed by mild reduction with NaCNBH3.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azidas
/
Trissacarídeos
/
Campylobacter jejuni
/
Antígenos O
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article