Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.
Bioorg Med Chem Lett
; 14(7): 1761-4, 2004 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-15026066
ABSTRACT
A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Neuropeptídeo Y
/
Aminopiridinas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article