2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.
Antimicrob Agents Chemother
; 48(4): 1422-5, 2004 Apr.
Article
em En
| MEDLINE
| ID: mdl-15047559
ABSTRACT
Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Replicação Viral
/
Vírus da Doença de Borna
/
Desoxicitidina
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article