Estrogen modulates ghrelin expression in the female rat stomach.
Peptides
; 25(2): 289-97, 2004 Feb.
Article
em En
| MEDLINE
| ID: mdl-15063011
ABSTRACT
Ghrelin was recently identified as an endogenous ligand for GH secretagogue receptor. In this study, we investigated the effects of ovariectomy on the numbers of ghrelin-immunopositive and -expressing cells, ghrelin mRNA levels, and plasma ghrelin concentrations in 4- and 9-week-old female rats. Three days after ovariectomy, the number of ghrelin cells and plasma ghrelin level significantly increased in both 4- and 9-week-old rats and the ghrelin mRNA level also increased in 4-week-old rats. These responses were reversed by 17beta-estradiol replacement. We also found that ghrelin-immunopositive cells express estrogen receptor alpha. These results suggested that estrogen is involved in the regulation of ghrelin expression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovariectomia
/
Hormônios Peptídicos
/
Estradiol
/
Mucosa Gástrica
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article