Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.
Neuron
; 42(1): 37-49, 2004 Apr 08.
Article
em En
| MEDLINE
| ID: mdl-15066263
ABSTRACT
Ena/VASP proteins play important roles in axon outgrowth and guidance. Ena/VASP activity regulates the assembly and geometry of actin networks within fibroblast lamellipodia. In growth cones, Ena/VASP proteins are concentrated at filopodia tips, yet their role in growth cone responses to guidance signals has not been established. We found that Ena/VASP proteins play a pivotal role in formation and elongation of filopodia along neurite shafts and growth cone. Netrin-1-induced filopodia formation was dependent upon Ena/VASP function and directly correlated with Ena/VASP phosphorylation at a regulatory PKA site. Accordingly, Ena/VASP function was required for filopodial formation from the growth cone in response to global PKA activation. We propose that Ena/VASP proteins control filopodial dynamics in neurons by remodeling the actin network in response to guidance cues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Pseudópodes
/
Proteínas de Transporte
/
Moléculas de Adesão Celular
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Proteínas de Caenorhabditis elegans
/
Fatores de Crescimento Neural
/
Neurônios
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article