Successful treatment of life-threatening human herpesvirus-6 encephalitis with donor lymphocyte infusion in a patient who had undergone human leukocyte antigen-haploidentical nonmyeloablative stem cell transplantation.
Transplantation
; 77(6): 835-8, 2004 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-15077022
ABSTRACT
BACKGROUND:
Encephalitis as the result of human herpesvirus (HHV)-6 is usually fatal when it is resistant to antiviral drugs.METHODS:
We describe a patient who developed HHV-6 encephalitis after human leukocyte antigen-haploidentical transplantation using a reduced intensity regimen.RESULTS:
The patient developed severe disorientation, amnesia, and tremors on day 28. Magnetic resonance imaging of the brain revealed limbic encephalitis, and the cerebrospinal fluid sample was positive for only HHV-6 in polymerase chain reaction analysis. Neither ganciclovir nor foscarnet was effective. The patient recovered from the critical condition of HHV-6 encephalitis after donor lymphocyte infusion (DLI). Almost all of his symptoms resolved, polymerase chain reaction tests for HHV-6 in the cerebrospinal fluid were negative, and magnetic resonance imaging findings were normal.CONCLUSIONS:
This is the first report of DLI as a treatment for HHV-6 encephalitis and the first report of DLI from an human leukocyte antigen-haploidentical donor as a treatment for life-threatening viral infection.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Linfócitos
/
Herpesvirus Humano 6
/
Encefalite Viral
/
Infecções por Roseolovirus
/
Transplante de Células-Tronco
/
Antígenos HLA
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article