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In vitro-in vivo antifungal evaluation and structure-activity relationships of 3H-1,2-dithiole-3-thione derivatives.
Giannini, Fernando A; Aimar, Mario L; Sortino, Maximiliano; Gomez, Roxana; Sturniollo, Alejandro; Juarez, Americo; Zacchino, Susana; de Rossi, Rita H; Enriz, Ricardo D.
Afiliação
  • Giannini FA; Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis (UNSL), Chacabuco y Pedernera, San Luis 5700, Argentina.
Farmaco ; 59(4): 245-54, 2004 Apr.
Article em En | MEDLINE | ID: mdl-15081341
As part of our project devoted to the search of new antifungal agents, we report here the in vitro-in vivo antifungal evaluations and a structure-activity relationship (SAR) study of 17 thione derivatives. Some compounds of this series exhibited remarkable antifungal activity against a broad spectrum of pathogenic opportunistic fungi. SAR studies provide a useful information for the determination of the minimum structural requirements for producing the biological response.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tionas / Tiofenos / Antifúngicos Limite: Animals / Humans Idioma: En Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tionas / Tiofenos / Antifúngicos Limite: Animals / Humans Idioma: En Ano de publicação: 2004 Tipo de documento: Article