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Natural history of decompensated hepatitis C virus-related cirrhosis. A study of 200 patients.
Planas, Ramon; Ballesté, Belén; Alvarez, Marco Antonio; Rivera, Monica; Montoliu, Silvia; Galeras, Josep Anton; Santos, Justiniano; Coll, Susanna; Morillas, Rosa Maria; Solà, Ricard.
Afiliação
  • Planas R; Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Universitat Autónoma de Barcelona, Badalona, Spain. rplanas@ns.hugtip.scs.es
J Hepatol ; 40(5): 823-30, 2004 May.
Article em En | MEDLINE | ID: mdl-15094231
BACKGROUND/AIMS: Since few data are available concerning the clinical course of decompensated hepatitis C virus (HCV)-related cirrhosis, the aim of the present study was to define the natural long-term course after the first hepatic decompensation. METHODS: Cohort of 200 consecutive patients with HCV-related cirrhosis, and without known hepatocellular carcinoma (HCC), hospitalized for the first hepatic decompensation. RESULTS: Ascites was the most frequent first decompensation (48%), followed by portal hypertensive gastrointestinal bleeding (PHGB) (32.5%), severe bacterial infection (BI) (14.5%) and hepatic encephalopathy (HE) (5%). During follow-up (34+/-2 months) there were 519 readmissions, HCC developed in 33 (16.5%) patients, and death occurred in 85 patients (42.5%). The probability of survival after diagnosis of decompensated cirrhosis was 81.8 and 50.8% at 1 and 5 years, respectively. HE and/or ascites as the first hepatic decompensation, baseline Child-Pugh score, age, and presence of more than one decompensation during follow-up were independently correlated with survival. CONCLUSIONS: Once decompensated HCV-related cirrhosis was established, patients showed not only a very high frequency of readmissions, but also developed decompensations different from the initial one. These results contribute to defining the natural course and prognosis of decompensated HCV-related cirrhosis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C Crônica / Cirrose Hepática Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2004 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatite C Crônica / Cirrose Hepática Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2004 Tipo de documento: Article