The role of endogenous and exogenous DNA damage and mutagenesis.
Curr Opin Genet Dev
; 14(1): 5-10, 2004 Feb.
Article
em En
| MEDLINE
| ID: mdl-15108798
ABSTRACT
The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and exciting contributions to our increasing understanding of the initiation and progression of neoplasia in humans. This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance of DNA damage and its contribution to mutagenesis, and DNA damage checkpoint regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Mutagênese
/
Reparo do DNA
/
Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article