The diploid genome sequence of Candida albicans.
Proc Natl Acad Sci U S A
; 101(19): 7329-34, 2004 May 11.
Article
em En
| MEDLINE
| ID: mdl-15123810
ABSTRACT
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Genoma Fúngico
/
Diploide
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article