Surveillance of susceptibility patterns in 1297 European and US anaerobic and capnophilic isolates to co-amoxiclav and five other antimicrobial agents.
J Antimicrob Chemother
; 53(6): 1039-44, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15128729
ABSTRACT
In vitro susceptibility data were collected for co-amoxiclav and other antimicrobial agents against 1297 recent anaerobe isolates collected in Europe and the USA. The co-amoxiclav (amoxicillin/clavulanic acid) MIC(50/90)s (amoxicillin/clavulanic acid concentration in a ratio of 21, expressed in terms of amoxicillin concentration in mg/L) were 0.5/4 for Bacteroides fragilis, =0.125/1 for Prevotella species, =0.125/0.25 for Fusobacterium nucleatum, 0.5/1 for Eikenella corrodens, 0.25/8 for Peptostreptococcus anaerobius, =0.125/0.5 for Micromonas (Peptostreptococcus) micros, =0.25/0.5 for Fingoldia (Peptostreptococcus) magna, and =0.125/0.125 for Porphyromonas species. The co-amoxiclav susceptibility rate for B. fragilis was 94.6%, for P. anaerobius 84.3% and for all other species tested 100%. These data indicate that co-amoxiclav remains an effective drug for the antimicrobial treatment and prophylaxis of many anaerobic infections. Among the comparator drugs, metronidazole was very active against all bacterial species (>96% susceptible) except E. corrodens (MIC(50/90) of >32/>64 mg/L), which is a capnophilic organism. Imipenem was also highly active against all species (>98% susceptible). Levofloxacin and clindamycin were the least potent agents tested, particularly against Bacteroides, Prevotella and Peptostreptococcus (levofloxacin susceptibility rates Bacteroides 72.7%, Prevotella 71.5%, F. magna 72.4%; clindamycin susceptibility rates Bacteroides 79.5%, Prevotella 92.1%, F. magna 84.7%).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias Anaeróbias
/
Infecções Bacterianas
/
Vigilância da População
/
Combinação Amoxicilina e Clavulanato de Potássio
/
Quimioterapia Combinada
/
Anti-Infecciosos
Tipo de estudo:
Screening_studies
Limite:
Humans
País/Região como assunto:
America do norte
/
Europa
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article