Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs.
FASEB J
; 18(10): 1093-5, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15132974
ABSTRACT
Ischemia-reperfusion injury, a clinical problem during cardiac surgery, involves worsened adenosine trisphosphate (ATP) generation and damage to the heart. We studied carbon monoxide (CO) pretreatment, proven valuable in rodents but not previously tested in large animals, for its effects on pig hearts subjected to cardiopulmonary bypass with cardioplegic arrest. Hearts of CO-treated pigs showed significantly higher ATP and phosphocreatine levels, less interstitial edema, and apoptosis of cardiomyocytes and required fewer defibrillations after bypass. We conclude that treatment with CO improves the energy status, prevents edema formation and apoptosis, and facilitates recovery in a clinically relevant model of cardiopulmonary bypass surgery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monóxido de Carbono
/
Ponte Cardiopulmonar
/
Cardiotônicos
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Traumatismo por Reperfusão Miocárdica
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Isquemia Miocárdica
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Coração
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article