1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists.
J Med Chem
; 47(11): 2833-8, 2004 May 20.
Article
em En
| MEDLINE
| ID: mdl-15139761
ABSTRACT
With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H(3) receptor. The most potent amides had antagonist potencies in the subnanomolar range.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Receptores Histamínicos H3
/
Antagonistas dos Receptores Histamínicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article