N-isoquinolin-5-yl-N'-aralkyl-urea and -amide antagonists of human vanilloid receptor 1.
Bioorg Med Chem Lett
; 14(12): 3053-6, 2004 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-15149643
ABSTRACT
Starting from a low micromolar agonist lead identified by high-throughput screening, series of N-isoquinolin-5-yl-N'-aralkyl ureas and analogous amides were developed as potent antagonists of human vanilloid receptor 1 (VR1). The synthesis and structure-activity relationships (SAR) of the series are described.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Droga
/
Ureia
/
Amidas
/
Isoquinolinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article