Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain.
Nat Struct Mol Biol
; 11(6): 576-7, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15156196
ABSTRACT
We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Nucleicos
/
Proteínas de Drosophila
/
Complexo de Inativação Induzido por RNA
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article