Restricted expression of ETn-related sequences during post-implantation mouse development.
Gene Expr Patterns
; 4(4): 467-71, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15183314
ABSTRACT
In a screen for potential targets of regulation by TWIST in mouse embryos we isolated a fragment with homology to type II early transposon (ETn) and type D endogenous provirus (MusD) elements. Whole-mount in situ hybridization to E7.5-E13.5 mouse embryos reveals a tissue- and stage-specific expression pattern that contrasts with the previously reported lack of expression of ETn elements in mouse embryos beyond late gastrulation. Transcripts were detected in the epiblast at E7.5 and in the neural tube from E8.5 to E10.5. Later expression is predominantly confined to the mesodermal tissues of craniofacial structures, limb buds and somites. The tissue specificity of expression suggests tight regulation of the activity of this early transposon element during embryogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica no Desenvolvimento
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Retrovirus Endógenos
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Desenvolvimento Embrionário
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Gástrula
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article