Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome.
Mod Pathol
; 17(7): 879-83, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15197401
ABSTRACT
A 76-year-old man presented with leukostasis syndrome, including oculodynia, blurred vision, and visual field defects, due to mantle cell lymphoma, prolymphocytoid variant, with marked leukocytosis, 1227 x 10(9)/l. He had splenomegaly but no lymphadenopathy or hepatomegaly. The tumor cells were CD5+, CD19+, CD20+, FMC-7+, and kappa light chain restricted. Immunohistochemistry showed expression of p53 and of cyclin D1. Fluorescent in situ hybridization demonstrated t(11;14) with translocation between CYCLIN D1 and the immunoglobulin heavy-chain genes. The patient received leukapheresis and aggressive chemotherapy, but the leukocyte count remained above 100 x 10(9)/l. The patient's condition rapidly deteriorated with lymphomatous infiltration of his lungs and soft tissues, and he expired 6 months after diagnosis. While it is known that mantle cell lymphoma may have a leukemic phase, the degree of leukocytosis in this case exceeds that previously reported in the literature and resulted in a clinical syndrome of leukostasis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Prolinfocítica
/
Leucostasia
/
Linfoma de Célula do Manto
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article