Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats.
J Toxicol Environ Health A
; 67(13): 979-86, 2004 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-15205029
ABSTRACT
The aim of this study was to determine the effects of streptozotocin-induced diabetes on plasma reduced glutathione (GSH) and S-nitrosoglutathione (GSNO) levels. Further, the study investigated whether an antioxidant, pineal hormone melatonin, could protect against STZ-induced effects. STZ significantly decreased plasma GSH but increased the levels of plasma GSNO. Daily supplementation with melatonin restored plasma thiol to control values. Data suggest that STZ-induced hyperglycemia and compounds that act as scavengers of free radicals and peroxynitrite like melatonin may exert protection against STZ-induced toxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Suplementos Nutricionais
/
S-Nitrosoglutationa
/
Diabetes Mellitus Experimental
/
Glutationa
/
Melatonina
/
Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article