Turning back the clock on neural progenitors.
Bioessays
; 26(7): 711-4, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15221852
ABSTRACT
Drosophila neural progenitor cells, or neuroblasts, alter their transcriptional profile over time to produce different neural cell types. A recent paper by Pearson and Doe shows that older neuroblasts can be reprogrammed to behave like young neuroblasts, and to produce early neural cell types, simply by expressing the transcription factor, Hunchback. The authors show that competence to respond to Hunchback diminishes over time. Manipulating neural progenitors in this way may have important implications for therapeutic uses of neural stem cells.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Fatores de Transcrição
/
Proteínas de Drosophila
/
Proteínas de Ligação a DNA
/
Drosophila melanogaster
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article