The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.
Proc Natl Acad Sci U S A
; 101(27): 10006-11, 2004 Jul 06.
Article
em En
| MEDLINE
| ID: mdl-15226503
ABSTRACT
The important anticancer drug Taxol (paclitaxel) binds to tubulin in a stoichiometric ratio and promotes its assembly into microtubules. The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have been made. In this work we present experimental and theoretical evidence that Taxol adopts a T-shaped conformation when it is bound to tubulin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tubulina (Proteína)
/
Paclitaxel
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article