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Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma.
Sis, Banu; Sagol, Ozgul; Küpelioglu, Ali; Sokmen, Selman; Terzi, Cem; Fuzun, Mehmet; Ozer, Erdener; Bishop, Paul.
Afiliação
  • Sis B; Department of Pathology, School of Medicine, Dokuz Eylül University, Inciralti, Izmir 35340, Turkey. banu.sis@deu.edu.tr
Pathol Res Pract ; 200(5): 379-87, 2004.
Article em En | MEDLINE | ID: mdl-15239346
Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumor invasion and metastasis. Therefore, we aimed at investigating the prognostic significance of MMP-2, CD, and TN-C expressions in primary colorectal cancer. Overall, 112 colorectal adenocarcinomas were included in the present study. MMP-2, CD, and TN-C expressions were evaluated by immunohistochemistry and correlated with clinicopathologic prognostic parameters and survival. Diffuse stromal TN-C immunostaining was found to be significantly correlated with advanced stage and shorter survival time (p = 0.002 and 0.02, respectively). MMP-2 expression was found to correlate with lymph vessel invasion (p = 0.006) and stage (p = 0.03). CD expression was related to depth of invasion (p = 0.005). No significant relationship was found between survival and MMP-2 and CD expression (p > 0.05). In multivariate analysis, stage and vascular invasion were independent prognostic factors, whereas TN-C did not retain a clear independent relationship to survival (p > 0.05). Our findings suggest that TN-C expression may be a potential prognostic marker in colorectal carcinoma. However, MMP-2 and CD do not appear to be significant indicators of survival.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Adenocarcinoma / Catepsina D / Tenascina / Metaloproteinase 2 da Matriz Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2004 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Adenocarcinoma / Catepsina D / Tenascina / Metaloproteinase 2 da Matriz Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2004 Tipo de documento: Article