Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease.
Arch Neurol
; 61(7): 1104-7, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15262742
ABSTRACT
BACKGROUND:
The different distribution of pathologic features in frontotemporal dementia (FTD) and Alzheimer disease (AD) predicts a predominant dysexecutive syndrome in FTD. The Frontal Assessment Battery (FAB) has previously been validated in diseases associated with a frontal lobe dysfunction.OBJECTIVE:
To evaluate the sensitivity of the FAB to differentiate FTD and AD.DESIGN:
Comparison study.SETTING:
Memory Clinic of the Salpêtrière Hospital, Paris, France. PATIENTS Twenty-six patients with FTD and 64 patients with AD. MAIN OUTCOMEMEASURES:
Comparison of FAB and Mini-Mental State Examination (MMSE) scores between patients with FTD and those with AD.RESULTS:
The mean +/- SD FAB scores significantly differed between patients with FTD (7.6 +/- 4.2) and those with AD (12.6 +/- 3.7) (P<.001), but not MMSE scores. The FAB correctly identified 78.9% of the patients. These results were maintained in a subgroup of mildly demented patients (MMSE score, > or =24). In these patients, a cutoff score of 12 on the FAB was optimal to differentiate both disorders (sensitivity, 77%; specificity, 87%).CONCLUSIONS:
The FAB takes less than 10 minutes to administer and provides an objective measure to distinguish FTD from AD in mildly demented patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Demência
/
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article