Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.
J Neuroimmunol
; 153(1-2): 171-82, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15265675
ABSTRACT
Intraplantar (i.pl.) injection of small doses of capsaicin has been shown to produce hyperalgesia and upregulation of the levels of proinflammatory cytokines. The present work aimed at investigating the possible mediation of these effects by sensory neuropeptides and mast cells. Various groups of rats received i.pl. injection of capsaicin alone or preceded by the injection of antagonists to substance P (SP), calcitonin gene-related protein (CGRP) and histamine (H1, H2) or the mast cell blocker ketotifen. All pretreatments prevented, in a dose-related manner, the capsaicin-induced hyperalgesia. The SP, H2 antagonists and ketotifen prevented the upregulation of all cytokines and nerve growth factor (NGF) levels, while the CGRP and H1 antagonists showed only attenuation of the NGF level.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Capsaicina
/
Histamina
/
Substância P
/
Peptídeo Relacionado com Gene de Calcitonina
/
Citocinas
/
Hiperalgesia
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article