Nerve growth factor: a protease that can activate plasminogen.
Proc Natl Acad Sci U S A
; 75(11): 5497-500, 1978 Nov.
Article
em En
| MEDLINE
| ID: mdl-152922
ABSTRACT
The single, highly stable form of mouse submandibular gland nerve growth factor (NGF), prepared as described by Young et al. [(1978) Biochemistry 17, 1490--1498] is a protease of restricted specificity that can convert plasminogen to plasmin. In the absence of plasminogen, NGF is not fibrinolytic, nor does it hydrolyze casein at a measurable rate. Treatment of NGF with diisopropyl fluorophosphate inhibits its ability to activate plasminogen as well as its capacity to hydrolyze certain synthetic arginine esters. These results indicate that NGF is a member of the class of serine proteases. Since NGF is known to be secreted at high concentrations in mouse saliva, it may serve to activate plasminogen (with subsequent fibrinolysis) somewhere in the alimentary tract. Plasminogen activation is the only known action of NGF upon a biologically important non-neural substrate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Hidrolases
/
Plasminogênio
/
Fatores de Crescimento Neural
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article