Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells.
Int J Biochem Cell Biol
; 36(11): 2250-7, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15313470
ABSTRACT
Although it is generally believed that, under normal conditions, the only source of immunoglobulin is mature B lymphocytes, we recently found several epithelium-derived carcinoma cell lines also express immunolglobulin-like protein. We extended our study to biopsy samples of human cervical tissues with various epithelial lesions. By in situ hybridization, we only detected a low level of mRNA for the immunoglobulin kappa light chain constant region in epithelia with cervicitis. However, in epithelia with dysplasia and carcinoma, the expression of mRNA for the kappa constant region was markedly increased. There was no significant difference in the level of mRNA for the kappa constant region between epithelial dysplasia and carcinoma. The aberrant expression of immunoglobulin kappa light chain constant region in dysplastic and cancerous cervical epithelial cells may serve as a marker for malignant cell transformation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cervicite Uterina
/
Displasia do Colo do Útero
/
Neoplasias do Colo do Útero
/
Cadeias kappa de Imunoglobulina
/
Células Epiteliais
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article