Remittive agents in pediatric rheumatology.
Curr Opin Rheumatol
; 16(5): 571-6, 2004 Sep.
Article
em En
| MEDLINE
| ID: mdl-15314497
ABSTRACT
PURPOSE OF REVIEW Children with rheumatic diseases frequently require therapy with disease-modifying antirheumatic drugs and/or biologic agents. Therapies that have been prospectively tested in adults are often used in children before full evaluation of their safety and efficacy. Published experience that may report "off-label" usage can be helpful in decision making, although such reports do not reduce the need for prospective clinical trials in children. The purpose of this review is to summarize the recent published evidence regarding efficacy (and safety, when available) of standard and novel agents used in pediatric rheumatic disease. RECENT FINDINGS:
Etanercept, one of three currently available tumor necrosis factor-alpha inhibitors has a juvenile idiopathic arthritis indication. Novel "off-label" uses in children for interleukin-1 receptor agonist (Anakinra), antiinterleukin-6 receptor antibody (MRA), and rituximab (anti-CD20 monoclonal antibody) are discussed.SUMMARY:
This review summarizes the published evidence that supports the use of selected disease-modifying antirheumatic drugs and novel biologic agents in children with rheumatic diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reumatologia
/
Produtos Biológicos
/
Doenças Reumáticas
/
Antirreumáticos
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article