Antiplasmodial activity of acetogenins and inhibitory effect on Plasmodium falciparum adenylate translocase.
J Chemother
; 16(4): 350-6, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15332710
ABSTRACT
Three Annonaceous acetogenins exhibited in vitro antimalarial activities on a chloroquine-resistant Plasmodium falciparum strain, with IC50s ranging from 5 to 10 microM. Structure-activity relationships showed that maximal antimalarial activity occurred in the presence of at least one tetrahydrofuran moiety and a synergistic action with chloroquine was observed. These acetogenins partially inhibited the P. falciparum adenylate translocase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Extratos Vegetais
/
Complexo I de Transporte de Elétrons
/
Álcoois Graxos
/
Aminoquinolinas
/
Lactonas
/
Antimaláricos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article