Modeling of competitive phosphono amino acid NMDA receptor antagonists.
J Med Chem
; 35(9): 1509-14, 1992 May 01.
Article
em En
| MEDLINE
| ID: mdl-1533680
ABSTRACT
A pharmacophore for the phosphono amino acid antagonists of the NMDA receptor has been developed using computer-based molecular modeling techniques. An important feature of this model is that a single binding site is proposed for the phosphonic acid moiety. All competitive antagonists we have examined incorporating amino acid and phosphonate groups in their structure fit the pharmacophore in energetically accessible conformations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de N-Metil-D-Aspartato
/
Organofosfonatos
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article