Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.

Rowbottom, Martin W; Tucci, Fabio C; Connors, Patrick J; Gross, Timothy D; Zhu, Yun-Fei; Guo, Zhiqiang; Moorjani, Manisha; Acevedo, Oscar; Carter, Lee; Sullivan, Susan K; Xie, Qiu; Fisher, Andrew; Struthers, R Scott; Saunders, John; Chen, Chen

Rowbottom, Martin W; Tucci, Fabio C; Connors, Patrick J; Gross, Timothy D; Zhu, Yun-Fei; Guo, Zhiqiang; Moorjani, Manisha; Acevedo, Oscar; Carter, Lee; Sullivan, Susan K; Xie, Qiu; Fisher, Andrew; Struthers, R Scott; Saunders, John; Chen, Chen.

Afiliação

Rowbottom MW; Department of Medicinal Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, USA. mrowbottom@neurocrine.com

Bioorg Med Chem Lett ; 14(19): 4967-73, 2004 Oct 04.

Article em En | MEDLINE | ID: mdl-15341961

Assuntos

Receptores LHRH/antagonistas & inibidores; Uracila/análogos & derivados; Humanos; Relação Estrutura-Atividade; Tiazóis; Tiofenos

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Uracila / Receptores LHRH Limite: Humans Idioma: En Ano de publicação: 2004 Tipo de documento: Article

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