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High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene.
Torres-Arzayus, Maria I; Font de Mora, Jaime; Yuan, Jing; Vazquez, Francisca; Bronson, Roderick; Rue, Montserrat; Sellers, William R; Brown, Myles.
Afiliação
  • Torres-Arzayus MI; Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
Cancer Cell ; 6(3): 263-74, 2004 Sep.
Article em En | MEDLINE | ID: mdl-15380517
The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, abnormal postweaning involution, and the development of malignant mammary tumors. Tumors are also increased in other organs, including the pituitary and uterus. AIB1 overexpression increases mammary IGF-I mRNA and serum IGF-I protein levels. In addition, IGF-I receptor and downstream signaling molecules are activated in primary mammary epithelial cells and mammary tumor cells derived from AIB1-tg mice. Knockdown of AIB1 expression in cultured AIB1-tg mammary tumor cells leads to reduced IGF-I mRNA levels and increased apoptosis, suggesting that an autocrine IGF-I loop underlies the mechanism of AIB1-induced oncogenesis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Adenocarcinoma / Transativadores / Neoplasias Mamárias Experimentais Tipo de estudo: Incidence_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2004 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Adenocarcinoma / Transativadores / Neoplasias Mamárias Experimentais Tipo de estudo: Incidence_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2004 Tipo de documento: Article