[Surgical procedure improvement to produce rat ischemia-reperfusion injury model with intraluminal suture].
Di Yi Jun Yi Da Xue Xue Bao
; 24(10): 1156-9, 2004 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-15485789
OBJECTIVE: To describe a modified surgical approach to produce rat ischemia-reperfusion injury model with intraluminal suture. METHODS: After exposure and ligation of the common carotid artery (CCA), the left external carotid artery and pterygopalatine artery were opened in which a 3-0 nylon suture was introduced intraluminally from the distal end of the ligature of the CCA using a scalp needle. Reperfusion injury was induced by withdrawal of the suture. RESULTS: The length of the suture was about 20.0+/-1.8 mm and the success rate of model establishment was nearly 70%. The rats developed typical symptoms and pathological manifestations after the surgery. CONCLUSION: This modified surgical approach is simple for model establishment and does not require special microsurgical skills to ensure the high success rate.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
/
Isquemia Encefálica
/
Procedimentos Neurocirúrgicos
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2004
Tipo de documento:
Article