Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells.
Bioorg Med Chem Lett
; 14(23): 5895-8, 2004 Dec 06.
Article
em En
| MEDLINE
| ID: mdl-15501064
ABSTRACT
A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E(2) production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Dinoprostona
/
Lipopolissacarídeos
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article