Arterial invasion predicts early mortality in stage I non-small cell lung cancer.
Ann Thorac Surg
; 78(5): 1748-53, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15511466
BACKGROUND: A retrospective study was performed to evaluate the association between arterial invasion and survival in patients with stage I non-small cell lung cancer. METHODS: One hundred patients were identified who had undergone complete anatomic resection as definitive treatment for stage I non-small cell lung cancer. The tumors were reviewed for the presence or absence of arterial invasion. Five-year survival data were obtained for all patients. RESULTS: The 100 patients had an overall 5-year survival of 61%. There were 64 stage IA patients with a 62% 5-year survival and 36 stage IB patients with a 58% 5-year survival. The 39 patients identified with arterial invasion had a 38% 5-year survival compared with a 73% 5-year survival in the 61 patients without arterial invasion (p < 0.001), with an unadjusted hazard ratio of 3.5 (p < 0.001). Multivariate analysis by stage IA versus IB and by size greater or less than 2 cm demonstrated hazard ratios of 3.5 and 4.0, respectively (p < 0.001). This difference was independent of demographic characteristics, tumor type, or grade. Subgroup analysis revealed a hazard ratio of 5.8 in patients with stage IA non-small cell lung cancer (p < 0.001) and 19.8 in patients with tumors < or = 2 cm (p = 0.006). CONCLUSIONS: Arterial invasion is present in a substantial percentage of patients with stage I non-small cell lung cancer and is adversely associated with survival.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias
/
Carcinoma Pulmonar de Células não Pequenas
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Neoplasias Pulmonares
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Invasividade Neoplásica
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article