Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist.
Regul Pept
; 124(1-3): 221-4, 2005 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-15544863
ABSTRACT
The vascular complications associated with type 1 diabetes are to some extent related to the dysfunction of the endothelium leading to an increased vascular permeability and plasma extravasation in the surrounding tissues. The various micro- and macro-vascular complications of diabetes develop over time, leading to nephropathy, retinopathy and neuropathy and cardiomyopathy. In the present study, the effect of a novel selective bradykinin B1 receptor (BKB1-R) antagonist, R-954, was investigated on the changes of vascular permeability in the skin and retina of streptozotocin (STZ)-induced type 1 diabetic rats. Plasma extravasation increased in the skin and retina of STZ-diabetic rats after 1 week and persisted over 4 weeks following STZ injection. Acute treatment with R-954 (2 mg/kg, bolus s.c.) highly reduced the elevated vascular permeability in both 1- and 4-week STZ-diabetic rats. These results showed that the inducible BKB1-R subtype modulates the vascular permeability of the skin and retina of type 1 diabetic rats and suggests that BKB1-R antagonists could have a beneficial role in diabetic neuropathy and retinopathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Pele
/
Permeabilidade Capilar
/
Diabetes Mellitus Tipo 1
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Antagonistas de Receptor B1 da Bradicinina
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article