Pharmacognosy and reverse pharmacognosy: a new concept for accelerating natural drug discovery.
IDrugs
; 7(11): 1017-27, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15551177
ABSTRACT
Combinatorial chemistry and high-throughput screening (HTS) have led to the identification of numerous agents that are active and selective in vitro. Identifying drugs that are active in vivo, however, remains a challenge. Traditional medicinal cures based on natural materials have proven useful for many populations worldwide, representing huge and disperse tracts of knowledge that are sometimes neglected in Western research due to differences in the concepts of illness. In this review we introduce a new approach, termed 'reverse pharmacognosy' (from diverse molecules to plants), which can be coupled with pharmacognosy (from biodiverse plants to molecules). Reverse pharmacognosy utilizes new techniques, such as HTS, virtual screening and a knowledge database containing the traditional uses of plants. Integrating pharmacognosy and reverse pharmacognosy in the research process may provide an efficient and rapid tool for natural drug discovery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmacognosia
/
Farmacologia
/
Fatores Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article