Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs.
Bioorg Med Chem
; 12(24): 6383-7, 2004 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-15556756
ABSTRACT
Two thia-DCK analogs (3a,b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 3a showed potent anti-HIV activity with an EC50 value of 0.14 microM and a therapeutic index of 1110. However, the corresponding 6-tert-butyl-substituted compound (3b) showed no suppression. The bioassay results indicated that thia-DCK analogs merit attention as potential HIV-1 inhibitors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fármacos Anti-HIV
Limite:
Humans
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article